Mansuetude was first used in English in the 14th century, and it derives from the Latin verb
mansuescere, which means "to tame."
Mansuescere itself comes from the noun
manus (meaning "hand") and the verb
suescere ("to accustom" or "to become accustomed"). Unlike
manus, which has many English descendants (including
manner,
emancipate, and
manicure),
suescere has only a few English progeny. One of them is
desuetude, which means
"disuse" and comes to us by way of Latin
desuescere ("to become unaccustomed"). Two others are
custom and
accustom, which derive via Anglo-French from Latin
consuescere, meaning "to accustom."
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